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Mini stroke memory loss9/23/2023 ![]() ![]() VCI harmonization standards (VCIHS) recommend the evaluation of four specified cognitive domains to conform with ASA/AHA diagnostic guidelines. In addition, neuropsychological protocols previously used to assess VCI have varied with respect to examined cognitive domains. Thus, we hypothesize that VaMCI patients with MI may differ in terms of infarct location or demographic features after adjusting the other demographic features, vascular risk factors, and infarct subtypes or locations. Interestingly, previous studies showed some difference in age, gender, risk factors, or hippocampal atrophy according to the subtypes of VaMCI or VCI, but these differences were not evaluated in the manner of multivariate analysis. Hippocampal atrophy is generally not associated with VCI and the correlation of MI with white matter hyperintensities, infarct location or laterality were reported after stroke, so the mechanisms of MI in VaMCI or VCI may be multifactorial. The prevalence of MI is about 23–55% from a review paper and is 21.4–66.5% from previous studies about VaMCI or VCI without dementia at 3–6 months after stroke. Memory domain has been considered as a key domain among all cognitive domains, however, little is known about the clinical characteristics of VaMCI with MI. Verbal memory declines over 3 years after stroke and impairment of verbal memory is associated with progression to dementia or vascular death. ![]() Memory impairment (MI) is a prerequisite for a diagnosis of vascular dementia according to DSM-IV criteria and a feature in the classification of VaMCI by ASA/AHA recommendation. Ĭognitive impairment after stroke is characterized by disturbance of frontal or executive function, however, several previous studies also indicated that clinical stroke causes subsequent poorer performance in multiple cognitive domains including memory. Moreover, it is recommended to apply these criteria in the study of VaMCI after stroke. The American Stroke Association/American Heart Association (ASA/AHA) recommended the following criteria for VaMCI: patient exhibits impairment in at least 1 of 4 cognitive domains (memory, executive/activation, visuospatial, language) display normal or mild impairments in daily living activities imaging results suggest cerebrovascular disease a temporal relationship exists between the stroke and the cognitive symptoms. ![]() While VaMCI sometimes improves with time, it is associated with an elevated risk of dementia. Vascular mild cognitive impairment (VaMCI) is a subtype of vascular cognitive impairment (VCI) and commonly follows stroke. MI is associated with sex and infarct location in VaMCI patients. Multiple logistic analyses revealed that male sex (odds ratio 3.07, 95% confidence interval 1.12-8.42), left-side infarcts (OR 3.14, 95% CI 1.37-7.20), and basal ganglia/internal capsule infarcts (OR 4.53, 95% CI 1.55-13.22) were associated with MI after adjusting other demographic variables, vascular risk factors, and subtypes of stroke. Proportions of men and of left side infarcts were higher in VaMCI with MI than those without (75.9 vs. VaMCI was diagnosed in 141 patients, and 58 (41.1%) exhibited MI. The association between MI and demographic features, stroke risk factors, and infarct location was assessed. MethodsĪ prospective multicenter study enrolled 353 acute ischemic stroke patients who underwent evaluation using the Korean Vascular Cognitive Impairment Harmonization Standard Neuropsychological Protocol at three months after onset. VaMCI patients with MI may differ in terms of infarct location or demographic features, so we evaluated the clinical characteristics associated with MI in patients with VaMCI. The American Stroke Association/American Heart Association recommended the criteria for diagnosis of vascular cognitive impairment and memory impairment (MI) is a feature in the classification of vascular mild cognitive impairment (VaMCI). ![]()
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